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Article

Beyond Mendelian randomization: how to interpret evidence of shared genetic predictors.

Journal of clinical epidemiology - 1 Jan 2016

Burgess Stephen, Butterworth Adam S, Thompson John R

Abstract excerpt

OBJECTIVE: Mendelian randomization is a popular technique for assessing and estimating the causal effects of risk factors. If genetic variants which are instrumental variables for a risk factor are shown to be additionally associated with a disease outcome, then the risk factor is a cause of the disease. However, in many cases, the instrumental variable assumptions are not plausible, or are in doubt. In this...

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Identifiers

PMID: 26291580
DOI: 10.1016/j.jclinepi.2015.08.001
PMCID: PMC4687951

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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