Article
Mendelian randomization studies: a review of the approaches used and the quality of reporting.
International journal of epidemiology - 1 Apr 2015
Boef Anna G C, Dekkers Olaf M, le Cessie Saskia
Abstract excerpt
BACKGROUND: Mendelian randomization (MR) studies investigate the effect of genetic variation in levels of an exposure on an outcome, thereby using genetic variation as an instrumental variable (IV). We provide a meta-epidemiological overview of the methodological approaches used in MR studies, and evaluate the discussion of MR assumptions and reporting of statistical methods. METHODS: We searched PubMed, Medline,...
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