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Mendelian randomization for cardiovascular diseases: principles and applications

18 Oct 2023

Abstract excerpt

Large-scale genome-wide association studies conducted over the last decade have uncovered numerous genetic variants associated with cardiometabolic traits and risk factors. These discoveries have enabled the Mendelian randomization (MR) design, which uses genetic variation as a natural experiment to improve causal inferences from observational data. By analogy with the random assignment of treatment in randomized...

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PMID: 37935836
DOI: 10.1093/eurheartj/ehad736

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