Article
Mendelian randomization: use of genetics to enable causal inference in observational studies.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 May 2010
Verduijn Marion, Siegerink Bob, Jager Kitty J, Zoccali Carmine, Dekker Friedo W
Abstract excerpt
The aim of aetiologic studies in epidemiology is to investigate whether factors are causally related to diseases and therefore become a potential target for therapeutic interventions. Mendelian randomization enables estimation of causal relationships in observational studies using genetic variants as instrumental variables. An instrumental variable is a variable that can be considered to mimic the coin toss in a...
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