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Haploidy in somatic cells is induced by mature oocytes in mice

25 Jan 2022

Abstract excerpt

Haploidy is naturally observed in gametes; however, attempts of experimentally inducing haploidy in somatic cells have not been successful. Here, we demonstrate that the replacement of meiotic spindles in mature metaphases II (MII) arrested oocytes with nuclei of somatic cells in the G0/G1 stage of cell cycle results in the formation of de novo spindles consisting of somatic homologous chromosomes comprising of...

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PMID: 35079104
DOI: 10.1038/s42003-022-03040-5

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