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Article

Generation of medaka fish haploid embryonic stem cells.

Science (New York, N.Y.) - 16 Oct 2009

Yi Meisheng, Hong Ni, Hong Yunhan

Abstract excerpt

Haploid embryonic stem (ES) cells combine haploidy and pluripotency, enabling direct genetic analyses of recessive phenotypes in vertebrate cells. Haploid cells have been elusive for culture, due to their inferior growth and genomic instability. Here, we generated gynogenetic medaka embryos and obtained three haploid ES cell lines that retained pluripotency and competitive growth. Upon nuclear transfer into...

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Identifiers

PMID: 19833967
DOI: 10.1126/science.1175151

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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