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Meiotic spindle formation in mammalian oocytes: implications for human infertility†

12 Jan 2018

Abstract excerpt

In the final stage of oogenesis, mammalian oocytes generate a meiotic spindle and undergo chromosome segregation to yield an egg that is ready for fertilization. Herein, we describe the recent advances in understanding the mechanisms controlling formation of the meiotic spindle in metaphase I (MI) and metaphase II (MII) in mammalian oocytes, and focus on the differences between mouse and human oocytes. Unlike...

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PMID: 29342242
DOI: 10.1093/biolre/iox145

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