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The functional significance of centrosomes in mammalian meiosis, fertilization, development, nuclear transfer, and stem cell differentiation

28 Apr 2009

Abstract excerpt

Centrosomes had been discovered in germ cells and germ cells continue to provide excellent but also challenging material in which to study complex centrosomal dynamics. The present review highlights the importance of centrosomes for meiotic spindle integrity and the susceptibility of meiotic spindle centrosomes to aging and drugs or toxic agents which may be associated with female infertility, aneuploidy, and...

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PMID: 19402157
DOI: 10.1002/em.20493

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