Article

Human oocytes harbouring damaged dna can complete meiosis-i

2019-09-05

Abstract excerpt

<h4>ABSTRACT</h4> Chromosomal abnormalities such as aneuploidies and DNA damage are considered a major threat to the establishment of healthy eggs and embryos. Recent landmark studies showed that mouse oocytes with damaged DNA can resume meiosis and undergo Germinal Vesicle Breakdown (GVBD), but then arrest in metaphase of meiosis-I in a process involving Spindle Assembly Checkpoint (SAC) signalling. Such a mecha...

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Literature Corpus work: f3aba18e-3a43-5c38-b363-e447df564e40
DOI: 10.1101/752113

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