Article

Hybrid female sterility due to cohesin protection errors in oocytes

2025-02-17

Abstract excerpt

Hybrid incompatibility can lead to lethality and sterility of F1 hybrids, contributing to speciation. Here we found that female hybrids between Mus musculus domesticus and Mus spicilegus mice are sterile due to the failure of homologous chromosome separation in oocyte meiosis I, producing aneuploid eggs. This non-separation phenotype was driven by the mis- localization of the cohesin protector, SGO2, along the c...

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Literature Corpus work: d7543a7c-6f0e-5a07-b599-fe501a202755
DOI: 10.1101/2025.02.16.638358

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