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Article

Maternal spindle transfer overcomes embryo developmental arrest caused by ooplasmic defects in mice.

eLife - 29 Apr 2020

Costa-Borges Nuno, Spath Katharina, Miguel-Escalada Irene, Mestres Enric, Balmaseda Rosa, Serafín Anna, Garcia-Jiménez Maria, Vanrell Ivette, González Jesús, Rink Klaus, Wells Dagan, Calderón Gloria

Abstract excerpt

The developmental potential of early embryos is mainly dictated by the quality of the oocyte. Here, we explore the utility of the maternal spindle transfer (MST) technique as a reproductive approach to enhance oocyte developmental competence. Our proof-of-concept experiments show that replacement of the entire cytoplasm of oocytes from a sensitive mouse strain overcomes massive embryo developmental arrest...

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Share to DNA, Mitochondrial
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32347793
DOI: 10.7554/eLife.48591
PMCID: PMC7259950

Genes

F2
F5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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