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Induction of Meiosis from Human Pluripotent Stem Cells

2024-06-01

Abstract excerpt

An in vitro model of human meiosis would accelerate research into this important reproductive process and development of therapies for infertility. We have developed a method to induce meiosis starting from male or female human pluripotent stem cells. We demonstrate that DNMT1 inhibition, retinoid signaling activation, and overexpression of regulatory factors (anti-apoptotic BCL2, and pro-meiotic HOXB5, BOLL, or...

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Literature Corpus work
68c6891e-5bf5-55f3-b9f6-e93bb2b37fd5
DOI
10.1101/2024.05.31.596483
Open publication

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Induction of Meiosis from Human Pluripotent Stem CellsDOI 10.1101/2024.05.31.596483
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