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Article

Polygenetic Risk Scores for Major Psychiatric Disorders Among Schizophrenia Patients, Their First-Degree Relatives, and Healthy Participants.

The international journal of neuropsychopharmacology - 21 Apr 2020

Ohi Kazutaka, Nishizawa Daisuke, Shimada Takamitsu, Kataoka Yuzuru, Hasegawa Junko, Shioiri Toshiki, Kawasaki Yasuhiro, Hashimoto Ryota, Ikeda Kazutaka

Abstract excerpt

BACKGROUND: The genetic etiology of schizophrenia (SCZ) overlaps with that of other major psychiatric disorders in samples of European ancestry. The present study investigated transethnic polygenetic features shared between Japanese SCZ or their unaffected first-degree relatives and European patients with major psychiatric disorders by conducting polygenic risk score (PRS) analyses. METHODS: To calculate PRSs for...

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PMID: 31900488
DOI: 10.1093/ijnp/pyz073
PMCID: PMC7171929

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