Article
Rapid progression from mild cognitive impairment to Alzheimer's disease in subjects with elevated levels of tau in cerebrospinal fluid and the APOE epsilon4/epsilon4 genotype.
Dementia and geriatric cognitive disorders - 1 Jan 2009
Blom Elin S, Giedraitis Vilmantas, Zetterberg Henrik, Fukumoto Hiroaki, Blennow Kaj, Hyman Bradley T, Irizarry Michael C, Wahlund Lars-Olof, Lannfelt Lars, Ingelsson Martin
Abstract excerpt
BACKGROUND/AIMS: Increased cerebrospinal fluid (CSF) tau, decreased CSF amyloid-beta42 (Abeta42) and the apolipoprotein E gene (APOE) epsilon4 allele predict progression from mild cognitive impairment (MCI) to Alzheimer's disease (AD). Here, we investigated these markers to assess their predictive value and influence on the rate of disease progression. METHODS: Using ELISA, we measured the CSF biomarkers in 47 AD...
Topics
- Aged
- Alzheimer Disease
- Amyloid beta-Peptides
- Apolipoprotein E4
- Biomarkers
- Cognition Disorders
- Disease Progression
- Female
- Genotype
- Humans