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Article

Preclinical effects of APOE ε4 on cerebrospinal fluid Aβ42 concentrations

23 Oct 2017

Abstract excerpt

BACKGROUND: (Aβ42) in patients with cognitive decline due to Alzheimer's disease (AD), as well as in cognitively healthy controls. Here, in a large cohort consisting solely of cognitively healthy individuals, we aimed to evaluate how the effect of APOE on CSF Aβ42 varies by age, to understand the association between APOE and the onset of preclinical AD. METHODS: APOE genotype and CSF Aβ42 concentration were...

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PMID: 29061195
DOI: 10.1186/s13195-017-0313-3

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