Article

Integrated Biofluid Proteomics Identified Dynamic Functional Biomarkers of <i>LRRK2</i> -Linked Parkinson’s Disease Progression

2025-12-29

Abstract excerpt

Leucine-rich repeat kinase 2 (LRRK2) variants are the most common cause of inherited Parkinson’s disease (PD), and the hyperactivity of the LRRK2 variants represent a validated drug target for PD. The penetration of common LRRK2 variants is incomplete, underscoring the need for molecular biomarkers that predict disease onset and guide therapeutics development. Here, we analyzed large datasets of cerebrospinal flui...

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Literature Corpus work: d55ed64e-e211-51af-938e-be1630f7857c
DOI: 10.64898/2025.12.22.25342856

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