Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased Phospho-AKT in Blood Cells from LRRK2 G2019S Mutation Carriers.

Annals of neurology - 1 Nov 2022

Garrido Alicia, Pérez-Sisqués Leticia, Simonet Cristina, Campoy-Campos Genís, Solana-Balaguer Júlia, Martín-Flores Núria, Fernández Manel, Soto Marta, Obiang Donina, Cámara Ana, Valldeoriola Francesc, Muñoz Esteban, Compta Yaroslau, Pérez-Navarro Esther, Alberch Jordi, Tolosa Eduardo, Martí María-José, Ezquerra Mario, Malagelada Cristina, Fernández-Santiago Rubén

Abstract excerpt

The purpose of this study was to investigate whether differential phosphorylation states of blood markers can identify patients with LRRK2 Parkinson's disease (PD). We assessed phospho(P)-Ser-935-LRRK2 and P-Ser-473-AKT levels in peripheral blood cells from patients with G2019S LRRK2-associated PD (L2PD, n = 31), G2019S LRRK2 non-manifesting carriers (L2NMC, n = 26), idiopathic PD (iPD, n = 25), and controls...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers
Share to Blood Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Share to Mutation

Share to Parkinson Disease

Share to Proto-Oncogene Proteins c-akt

Source

Open in PubMed Open full text

Identifiers

PMID: 35929078
DOI: 10.1002/ana.26469
PMCID: PMC9827833

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased Phospho-AKT in Blood Cells from LRRK2 G2019S Mutation Carriers.PMID 35929078Read ↗

Differential Phospho-Signatures in Blood Cells Identify LRRK2 G2019S Carriers in Parkinson's Disease.Semantic proximity Read ↗

An Assessment of LRRK2 Serine 935 Phosphorylation in Human Peripheral Blood Mononuclear Cells in Idiopathic Parkinson’s Disease and G2019S LRRK2 CohortsSemantic proximity Read ↗

In-depth mass-spectrometry reveals phospho-RAB12 as a blood biomarker of G2019S LRRK2-driven Parkinson’s diseaseSemantic proximity Read ↗

In-depth mass-spectrometry reveals phospho-RAB12 as a blood biomarker of G2019S LRRK2-driven Parkinson’sSemantic proximity Read ↗

Precision Stratification: Kinase Assay in Asian <i>LRRK2</i> Risk Carriers and Idiopathic Parkinson DiseaseSemantic proximity Read ↗

R1441G but not G2019S mutation enhances LRRK2 mediated Rab10 phosphorylation in human peripheral blood neutrophils.Semantic proximity Read ↗

Single molecule array measures of LRRK2 kinase activity in serum link Parkinson’s disease severity to peripheral inflammationSemantic proximity Read ↗

Beyond known mutations: Functional evidence for LRRK2 pathway activation in a subset of Parkinson’s disease patientsSemantic proximity Read ↗

Understanding LRRK2 kinase activity in preclinical models and human subjects through quantitative analysis of LRRK2 and pRab10Semantic proximity Read ↗

Comparative blood transcriptome analysis in idiopathic and LRRK2 G2019S-associated Parkinson's disease.Semantic proximity Read ↗

A leucine-rich repeat kinase 2 (LRRK2) pathway biomarker characterization study in patients with Parkinson's disease with and without LRRK2 mutations and healthy controls.Semantic proximity Read ↗

Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.