Back to search

Article

Precision Stratification: Kinase Assay in Asian <i>LRRK2</i> Risk Carriers and Idiopathic Parkinson Disease

2025-09-25

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Importance</h4> LRRK2 kinase inhibition is one of the most promising therapeutic strategies in Parkinson’s disease (PD), yet understanding of kinase activity in the Asian-prevalent p.G2385R and p.R1628P variants, each affecting 5–10% of PD patients, remains limited. Development of patient stratification and target engagement markers applicable across global cohorts is an urgent priority. <h...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
003327be-c3db-51a6-9f48-f52f624965cd
DOI
10.1101/2025.09.23.25336067
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Precision Stratification: Kinase Assay in Asian <i>LRRK2</i> Risk Carriers and Idiopathic Parkinson DiseaseDOI 10.1101/2025.09.23.25336067
Understanding LRRK2 kinase activity in preclinical models and human subjects through quantitative analysis of LRRK2 and pRab10Semantic proximity
Clinical and functional evidence for the pathogenicity of the LRRK2 p.Arg1067Gln variantSemantic proximity
<i>LRRK2</i> p.G2385R and p.R1628P Variants in a Multi-Ethnic Asian Parkinson’s Cohort: Epidemiology and Clinical InsightsSemantic proximity
Clinical and functional evidence for the pathogenicity of the LRRK2 p.Arg1067Gln variantSemantic proximity
Beyond known mutations: Functional evidence for LRRK2 pathway activation in a subset of Parkinson’s disease patientsSemantic proximity
An Assessment of LRRK2 Serine 935 Phosphorylation in Human Peripheral Blood Mononuclear Cells in Idiopathic Parkinson’s Disease and G2019S LRRK2 CohortsSemantic proximity
Functional and Structural Characterization of LRRK2 p.V1447L in Parkinson’s DiseaseSemantic proximity
Understanding LRRK2 kinase activity in preclinical models and human subjects through quantitative analysis of LRRK2 and pT73 Rab10Semantic proximity
A leucine-rich repeat kinase 2 (LRRK2) pathway biomarker characterization study in patients with Parkinson's disease with and without LRRK2 mutations and healthy controls.Semantic proximity
The Current State-of-the Art of LRRK2-Based Biomarker Assay Development in Parkinson’s DiseaseSemantic proximity
Single molecule array measures of LRRK2 kinase activity in serum link Parkinson’s disease severity to peripheral inflammationSemantic proximity
Distinct profiles of LRRK2 activation and Rab GTPase phosphorylation in clinical samples from different PD cohortsSemantic proximity
Select a neighboring publication to make it the new centre.