Article
Comparative blood transcriptome analysis in idiopathic and LRRK2 G2019S-associated Parkinson's disease.
Neurobiology of aging - 1 Feb 2016
Infante Jon, Prieto Carlos, Sierra María, Sánchez-Juan Pascual, González-Aramburu Isabel, Sánchez-Quintana Coro, Berciano José, Combarros Onofre, Sainz Jesús
Abstract excerpt
Patients with Parkinson's disease (PD) carrying the G2019S mutation of the LRRK2 gene provide an opportunity of studying in a homogeneous setting the molecular pathways involved in the pathogenesis of common idiopathic forms of PD. However, whether common mechanisms are involved in both conditions in not known. Here, we compared genome-wide gene expression (RNA sequencing) in peripheral blood between PD patients...
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