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Article

A murine Skint6 W168X allele contributes to autoimmune disease in a transgenic model.

Lupus - 1 Mar 2022

Ju Jiyu, Wang Hui, Lian Meng, Bao Yatao, Zhang Yanyan, Xu Zhiwei

Abstract excerpt

BACKGROUND: The genetic factor is a great driver of systemic lupus erythematosus. A Skint6 W168X allele was previously identified in the murine lupus susceptibility rec1d1 sublocus. The purpose of this study is to investigate the pathogenic role and mechanism of the Skint6 W168X allele in lupus autoimmune disease. METHODS: The gene-editing CRISPR/Cas9 system was used to generate transgenic models with the Skint6...

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PMID: 35045734
DOI: 10.1177/09612033221074544

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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