Article

Role of<i>STING/TMEM173</i>mutation in systemic lupus erythematosus: from animal model to intrinsic human genetics

2022-12-06

Abstract excerpt

<h4>Objective</h4> We aim to confirm the function of Sting/Tmem173 in pristane-induced lupus and identify the role of STING/TMEM173 variants in SLE susceptibility. <h4>Methods</h4> Pristane-induced lupus model was introduced in the Sting -deficient mice (ENU-induced Goldenticket mutant mice). Autoantibody, histopathology, and immunophenotypes were analyzed after pristane injection for six months. Isolated DNA from...

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Literature Corpus work: c7dd2236-9aa7-525d-896e-69c56aa27d2e
DOI: 10.1101/2022.12.02.22283012

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