Article
A single fas gene mutation changes lupus onset, severity, location, and molecular abnormalities in mice.
Current molecular medicine - 1 Jan 2015
Hu S, Ke S, Wang W, Ran H, Chen M, Zhang F, Qiu X, Jiang M, Zou C, Zhang R, Cao L, Wen Y, Fu R, Chen C
Abstract excerpt
Although genetic predisposition plays a major role in the progression of systemic lupus erythematosus (SLE) and its variation in symptoms, the precise relationships between genetic changes and disease status are not well understood. Here, to demonstrate the effect of a single gene mutation on disease etiology, we examined two mouse models of SLE with the same genetic background but different Fas genes. Mice with...
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