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Article

A bacterial artificial chromosome transgene with polymorphic Cd72 inhibits the development of glomerulonephritis and vasculitis in MRL-Faslpr lupus mice.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2013

Oishi Hisashi, Tsubaki Takahito, Miyazaki Tatsuhiko, Ono Masao, Nose Masato, Takahashi Satoru

Abstract excerpt

Systemic lupus erythematosus is considered to be under the control of polygenic inheritance, developing according to the cumulative effects of susceptibility genes with polymorphic alleles; however, the mechanisms underlying the roles of polygenes based on functional and pathological genomics remain uncharacterized. In this study, we substantiate that a CD72 polymorphism in the membrane-distal extracellular...

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Share to Antibodies, Antinuclear
Share to Antigens, Differentiation, B-Lymphocyte

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Chromosomes, Artificial, Bacterial

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Share to Mice, Inbred MRL lpr

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Source

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Identifiers

PMID: 23365086
DOI: 10.4049/jimmunol.1202196
PMCID: PMC3575566

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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