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Article

Genetic and cellular mechanisms of autoimmunity in lupus-prone B6.129-Sle16 mice

2017-01-01

Abstract excerpt

Genome sequencing and transcriptomic analyses are hypothesis-free approaches to identify genetic variants(s) and biological pathway(s) associated with a disease. T cells are paramount in the pathogenesis of systemic lupus erythematosus (SLE). Hyperactive CD4+ T cells can promote the production of auto-antibodies by offering excessive help to B cells. B6 congenic mice carrying the Sle16 locus (B6.129-Sle16) have in...

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Literature Corpus work
162ed491-1a11-5c38-ad18-4ec2beabf518
DOI
10.25560/75497
Open publication

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