Article

TASL is required for age-related B cell formation and autoimmunity

2025-08-02

Abstract excerpt

The autoimmune disease systemic lupus erythematosus (SLE) is associated with genetic variants in the X-linked gene CXORF21 , which encodes the protein TASL. TASL acts as an adaptor in the IRF5 pathway and is necessary for the phosphorylation of IRF5 in response to TLR7 or TLR9 stimulation. Here, we investigate the role of TASL in the humoral immune response, and in the development of lupus in the B6.MRL lpr muri...

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Identifiers and source

Literature Corpus work: dd0fff68-7ca4-578e-859f-dfb86dac8b98
DOI: 10.1101/2025.08.01.668068

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