Article
A Variant of sNASP Exacerbates Lymphocyte Subset Disorder and Nephritis in a Spontaneous Lupus Model Sle1.Yaa Mouse.
Mediators of inflammation - 1 Jan 2021
Zhang Jianye, Du Xiaoping, Wang Hui, Bao Yatao, Lian Meng, Xu Zhiwei, Ju Jiyu
Abstract excerpt
A variant of somatic nuclear autoantigenic sperm protein (sNASP) was identified from the murine lupus susceptibility locus Sle2c1 by whole exome sequencing (WES). Previous studies have shown that mutant sNASP could synergize with the Faslpr mutation in exacerbating autoimmunity and aggravating end-organ inflammation. In the current study, the sNASP mutation was introduced into Sle1.Yaa mice to detect whether it...
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