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Article

The lupus susceptibility locus Sle1 facilitates the peripheral development and selection of anti-DNA B cells through impaired receptor editing.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2014

Chang Soog-Hee, Kim Tae-Joo, Kim Young-Joo, Liu Yang, Min So-Youn, Park Min-Jung, Park Hyun-Sil, Lee Sun-Kyung, Nam Ki-Hoan, Kim Ho-Youn, Mohan Chandra, Kim Hang-Rae

Abstract excerpt

Systemic lupus erythematosus is characterized by the spontaneous production of IgG autoantibodies in patients and lupus-prone mice. In this study, we investigated the effect of the Sle1 lupus susceptibility locus on the peripheral development of 56R(+) anti-DNA transgenic B cells by tracking 56R(+) B cells in mice without (B6.56R) or with (B6.Sle1.56R) the Sle1 locus. Compared with B6.56R mice, B6.Sle1.56R mice...

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Share to Antibodies, Antinuclear
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24835399
DOI: 10.4049/jimmunol.1201558

Genes

BCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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