Article

<i> FAS <sup>lpr</sup> </i> gene dosage tunes the extent of lymphoproliferation and T cell differentiation in lupus

2023-11-02

Abstract excerpt

Sle1 and Fas lpr are two lupus susceptibility loci that lead to manifestations of systemic lupus erythematosus. To evaluate dosage effects of FAS lpr in determining cellular and serological phenotypes associated with lupus, we developed a new C57BL/6 (B6) congenic lupus strain, B6. Sle1/Sle1.Fas lpr /+ (sle1 homo .lpr het ) and compared it with B6. Fas lpr/lpr (lpr homo ), B6. Sle1/Sle1 (sle1 homo ),...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e0704d07-36d0-5854-a143-7ac258616618
DOI: 10.1101/2023.11.01.563607

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i> FAS <sup>lpr</sup> </i> gene dosage tunes the extent of lymphoproliferation and T cell differentiation in lupusDOI 10.1101/2023.11.01.563607Read

Genetic Dissection of SLESemantic proximity Read

Genetic interactions between susceptibility loci reveal epistatic pathogenic networks in murine lupus.Semantic proximity Read

Susceptibility genes in the pathogenesis of murine lupus.Semantic proximity Read

A single fas gene mutation changes lupus onset, severity, location, and molecular abnormalities in mice.Semantic proximity Read

The NZM2410-derived lupus susceptibility locus Sle2c1 increases Th17 polarization and induces nephritis in fas-deficient mice.Semantic proximity Read

Murine lupus susceptibility locus Sle1a requires the expression of two sub-loci to induce inflammatory T cells.Semantic proximity Read

The major murine systemic lupus erythematosus susceptibility locus Sle1 results in abnormal functions of both B and T cells.Semantic proximity Read

Genetics of systemic autoimmunity in mouse models of lupus.Semantic proximity Read

The lupus susceptibility locus Sle1 facilitates the peripheral development and selection of anti-DNA B cells through impaired receptor editing.Semantic proximity Read

Murine lupus susceptibility locus Sle1a controls regulatory T cell number and function through multiple mechanisms.Semantic proximity Read

Assessing the Molecular Validity of Spontaneous Lupus Mouse Models and Its Implication for Human StudiesSemantic proximity Read

Lupus Susceptibility Loci Predispose Mice to Clonal Lymphocytic Responses and Myeloid ExpansionSemantic proximity Read