Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Disease in the Pld4thss/thss Model of Murine Lupus Requires TLR9

1 Aug 2023

Abstract excerpt

Phospholipase D4 (PLD4) is an endolysosomal exonuclease of ssRNA and ssDNA, rather than a phospholipase as its name suggests. Human polymorphisms in the PLD4 gene have been linked by genome-wide association studies to systemic sclerosis, rheumatoid arthritis, and systemic lupus erythematosus. However, B6.129 Pld4-/- mice develop features of a distinct disease, macrophage activation syndrome, which is reversed in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoimmune and Inflammatory Disorders Research
Share to Immune Cell Function and Interaction
Share to Immunodeficiency and Autoimmune Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37555846
DOI: 10.4049/immunohorizons.2300058

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Disease in the Pld4thss/thss Model of Murine Lupus Requires TLR9PMID 37555846Read ↗

Cleavage of DNA and RNA by PLD3 and PLD4 limits autoinflammatory triggering by multiple sensors.Semantic proximity Read ↗

TLR9 Deficiency Leads to Accelerated Renal Disease and Myeloid Lineage Abnormalities in Pristane-Induced Murine LupusSemantic proximity Read ↗

PLD4 is a genetic determinant to systemic lupus erythematosus and involved in murine autoimmune phenotypesSemantic proximity Read ↗

Sustained NPSLE-like phenotype in the absence of systemic lupus-like disease in TLR7-deficient B6.Nba2 mice.Semantic proximity Read ↗

Elucidating the function of STING in systemic lupus erythematosus through the STING Goldenticket mouse mutantSemantic proximity Read ↗

An unexpected role for RNA-sensing toll-like receptors in a murine model of DNA accrual.Semantic proximity Read ↗

A murine Skint6 W168X allele contributes to autoimmune disease in a transgenic model.Semantic proximity Read ↗

Genetic and cellular mechanisms of autoimmunity in lupus-prone B6.129-Sle16 miceSemantic proximity Read ↗

Repeated TLR9 stimulation results in macrophage activation syndrome–like disease in miceSemantic proximity Read ↗

Genetic evidence for the role of plasmacytoid dendritic cells in systemic lupus erythematosusSemantic proximity Read ↗

sNASP mutation aggravates to the TLR4-mediated inflammation in SLE by TAK1 pathwaySemantic proximity Read ↗

Retention of ES cell-derived 129S genome drives NLRP1 hypersensitivity and transcriptional deregulation in <i> Nlrp3 <sup>−/−</sup> </i> miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.