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Harnessing Whole Genome Polygenic Risk Scores to Stratify Individuals Based on Cardiometabolic Risk Factors and Biomarkers at Age 10 in the Lifecourse-Brief Report.

Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 2022

Richardson Tom G, O'Nunain Katie, Relton Caroline L, Davey Smith George

Abstract excerpt

BACKGROUND: In this study, we investigated the capability of polygenic risk scores to stratify a cohort of young individuals into risk deciles based on 10 different cardiovascular traits and circulating biomarkers. METHODS: We first conducted large-scale genome-wide association studies using data on adults (mean age 56.5 years) enrolled in the UK Biobank study (n=393 193 to n=461 460). Traits and biomarkers...

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Identifiers

PMID: 35045726
DOI: 10.1161/ATVBAHA.121.316650
PMCID: PMC8860202

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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