Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fitness ranking of individual mutants drives patterns of epistatic interactions in HIV-1.

PloS one - 31 Mar 2011

Martínez Javier P, Bocharov Gennady, Ignatovich Anna, Reiter Jochen, Dittmar Matthias T, Wain-Hobson Simon, Meyerhans Andreas

Abstract excerpt

Fitness interactions between mutations, referred to as epistasis, can strongly impact evolution. For RNA viruses and retroviruses with their high mutation rates, epistasis may be particularly important to overcome fitness losses due to the accumulation of deleterious mutations and thus could influence the frequency of mutants in a viral population. As human immunodeficiency virus type 1 (HIV-1) resistance to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epistasis, Genetic
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutagenesis, Site-Directed

Share to Mutation

Share to Polymerase Chain Reaction

Share to Virus Replication

Share to Zidovudine

Source

Open in PubMed Open full text

Identifiers

PMID: 21483787
DOI: 10.1371/journal.pone.0018375
PMCID: PMC3069090

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fitness ranking of individual mutants drives patterns of epistatic interactions in HIV-1.PMID 21483787Read ↗

Predominance of positive epistasis among drug resistance-associated mutations in HIV-1 protease.Semantic proximity Read ↗

Predominance of positive epistasis among drug resistance-associated mutations in HIV-1 proteaseSemantic proximity Read ↗

Viral fitness: history and relevance for viral pathogenesis and antiviral interventionsSemantic proximity Read ↗

Limits to detecting epistasis in the fitness landscape of HIV.Semantic proximity Read ↗

Fitness variations and their impact on the evolution of antiretroviral drug resistance.Semantic proximity Read ↗

Estimating Relative Fitness in Viral Competition ExperimentsSemantic proximity Read ↗

Evidence for positive epistasis in HIV-1.Semantic proximity Read ↗

Additive Phenotypes Underlie Epistasis of Fitness Effects.Semantic proximity Read ↗

The impact of high‐order epistasis in the within‐host fitness of a positive‐sense plant RNA virusSemantic proximity Read ↗

Inferring genetic interactions from comparative fitness data.Semantic proximity Read ↗

Can modulation of viral fitness represent a target for anti-HIV-1 strategies?Semantic proximity Read ↗

Fitness epistasis and constraints on adaptation in a human immunodeficiency virus type 1 protein region.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.