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Article

Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies.

Nature - 1 Feb 2022

Cao Yunlong, Wang Jing, Jian Fanchong, Xiao Tianhe, Song Weiliang, Yisimayi Ayijiang, Huang Weijin, Li Qianqian, Wang Peng, An Ran, Wang Jing, Wang Yao, Niu Xiao, Yang Sijie, Liang Hui, Sun Haiyan, Li Tao, Yu Yuanling, Cui Qianqian, Liu Shuo, Yang Xiaodong, Du Shuo, Zhang Zhiying, Hao Xiaohua, Shao Fei, Jin Ronghua, Wang Xiangxi, Xiao Junyu, Wang Youchun, Xie Xiaoliang Sunney

Abstract excerpt

The SARS-CoV-2 B.1.1.529 (Omicron) variant contains 15 mutations of the receptor-binding domain (RBD). How Omicron evades RBD-targeted neutralizing antibodies requires immediate investigation. Here we use high-throughput yeast display screening1,2 to determine the profiles of RBD escaping mutations for 247 human anti-RBD neutralizing antibodies and show that the neutralizing antibodies can be classified by...

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Share to Angiotensin-Converting Enzyme 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Epitopes, B-Lymphocyte

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Source

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Identifiers

PMID: 35016194
DOI: 10.1038/s41586-021-04385-3
PMCID: PMC8866119

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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