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Article

Insights on the mutational landscape of the SARS-CoV-2 Omicron variant receptor-binding domain.

Cell reports. Medicine - 15 Feb 2022

Miller Nathaniel L, Clark Thomas, Raman Rahul, Sasisekharan Ram

Abstract excerpt

The Omicron variant features enhanced transmissibility and antibody escape. Here, we describe the Omicron receptor-binding domain (RBD) mutational landscape using amino acid interaction (AAI) networks, which are well suited for interrogating constellations of mutations that function in an epistatic manner. Using AAI, we map Omicron mutations directly and indirectly driving increased escape breadth and depth in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35233548
DOI: 10.1016/j.xcrm.2022.100527
PMCID: PMC8784435

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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