Article

Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift

2021-12-14

Abstract excerpt

<h4>SUMMARY</h4> The recently emerged SARS-CoV-2 Omicron variant harbors 37 amino acid substitutions in the spike (S) protein, 15 of which are in the receptor-binding domain (RBD), thereby raising concerns about the effectiveness of available vaccines and antibody therapeutics. Here, we show that the Omicron RBD binds to human ACE2 with enhanced affinity relative to the Wuhan-Hu-1 RBD and acquires binding to mous...

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Literature Corpus work: c64c1011-a354-5cea-a503-5c05f6433caa
DOI: 10.1101/2021.12.12.472269

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