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Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron

25 Jan 2022

Abstract excerpt

The SARS-CoV-2 Omicron variant with increased fitness is spreading rapidly worldwide. Analysis of cryo-EM structures of the spike (S) from Omicron reveals amino acid substitutions forging interactions that stably maintain an active conformation for receptor recognition. The relatively more compact domain organization confers improved stability and enhances attachment but compromises the efficiency of the viral...

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PMID: 35120603
DOI: 10.1016/j.cell.2022.01.019

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