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Article

An engineered ACE2 decoy neutralizes the SARS-CoV-2 Omicron variant and confers protection against infection in vivo

26 Apr 2022

Abstract excerpt

The Omicron (B.1.1.529) SARS-CoV-2 variant contains an unusually high number of mutations in the spike protein, raising concerns of escape from vaccines, convalescent serum, and therapeutic drugs. Here, we analyzed the degree to which Omicron pseudo-virus evades neutralization by serum or therapeutic antibodies. Serum samples obtained 3 months after two doses of BNT162b2 vaccination exhibited 18-fold lower...

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PMID: 35471044
DOI: 10.1126/scitranslmed.abn7737

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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