Characterization of SARS-CoV-2 Omicron spike RBD reveals significantly decreased stability, severe evasion of neutralizing-antibody recognition but unaffected engagement by decoy ACE2 modified for enhanced RBD binding

Abstract excerpt

The recent-emerging Omicron variant (B.1.1.529 lineage) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has raised serious public concern because of its rapid regional- and global-transmission. As of 11th January 2022, the Omicron variant has spread to 140 countries, territories or areas through infected air travelers, and the number is continuously increasing. 1 Currently, Omicron has outcompeted...

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