Article

Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies

2021-12-09

Abstract excerpt

The SARS-CoV-2 B.1.1.529 variant (Omicron) contains 15 mutations on the receptor-binding domain (RBD). How Omicron would evade RBD neutralizing antibodies (NAbs) requires immediate investigation. Here, we used high-throughput yeast display screening 1,2 to determine the RBD escaping mutation profiles for 247 human anti-RBD NAbs and showed that the NAbs could be unsupervised clustered into six epitope groups (A-F)...

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Literature Corpus work: cfe62493-37a7-5b9e-a7ec-d49b254294d0
DOI: 10.1101/2021.12.07.470392

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