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Structural delineation and computational design of SARS-CoV-2-neutralizing antibodies against Omicron subvariants

14 Jul 2023

Abstract excerpt

SARS-CoV-2 Omicron subvariants have evolved to evade receptor-binding site (RBS) antibodies that exist in diverse individuals as public antibody clones. We rationally selected RBS antibodies resilient to mutations in emerging Omicron subvariants. Y489 was identified as a site of virus vulnerability and a common footprint of broadly neutralizing antibodies against the subvariants. Multiple Y489-binding antibodies...

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PMID: 37452031
DOI: 10.1038/s41467-023-39890-8

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