Article

PRISM: ancestry-aware integration of tissue-specific genomic annotations enhances the transferability of polygenic scores

2025-11-13

Abstract excerpt

The limited transferability of polygenic scores (PGS) across populations constrains their clinical utility and risks exacerbating health disparities, given challenges in multi-ancestry training, fine-mapping, and variant prioritization using genomic annotations, particularly when biologically relevant reference resources are sparse or unavailable for the target population. Here, we introduce PRISM, a transfer lear...

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Literature Corpus work: 8a7cbf59-467f-5005-b9f3-fb2c4c89c5a7
DOI: 10.1101/2025.11.13.688144

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