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Complement dysregulation and Alzheimer's disease in Down syndrome

23 Sept 2022

Abstract excerpt

INTRODUCTION: Down syndrome (DS) is associated with immune dysregulation and a high risk of early onset Alzheimer's disease (AD). Complement is a key part of innate immunity and driver of pathological inflammation, including neuroinflammation in AD. Complement dysregulation has been reported in DS; however, the pattern of dysregulation and its relationship to AD risk is unclear. METHODS: Plasma levels of 14...

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PMID: 36149090
DOI: 10.1002/alz.12799

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