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Article

Cell Type-Specific Role of RNA Nuclease SMG6 in Neurogenesis.

Cells - 30 Nov 2021

Guerra Gabriela Maria, May Doreen, Kroll Torsten, Koch Philipp, Groth Marco, Wang Zhao-Qi, Li Tang-Liang, Grigaravičius Paulius

Abstract excerpt

SMG6 is an endonuclease, which cleaves mRNAs during nonsense-mediated mRNA decay (NMD), thereby regulating gene expression and controling mRNA quality. SMG6 has been shown as a differentiation license factor of totipotent embryonic stem cells. To investigate whether it controls the differentiation of lineage-specific pluripotent progenitor cells, we inactivated Smg6 in murine embryonic neural stem cells....

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Identifiers

PMID: 34943873
DOI: 10.3390/cells10123365
PMCID: PMC8699217

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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