Article
MiR-30e and miR-181d control radial glia cell proliferation via HtrA1 modulation.
Cell death & disease - 2 Aug 2012
Nigro A, Menon R, Bergamaschi A, Clovis Y M, Baldi A, Ehrmann M, Comi G, De Pietri Tonelli D, Farina C, Martino G, Muzio L
Abstract excerpt
The precise mechanisms by which microRNAs (miRNAs) contribute to the dynamic regulation of gene expression during the forebrain development are still partly elusive. Here we show that the depletion of miRNAs in the cerebral cortex and hippocampus, via genetic inactivation of Dicer after the onset of forebrain neurogenesis, profoundly impairs the morphological and proliferative characteristics of neural stem and...
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