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Article

Survival motor neuron protein regulates stem cell division, proliferation, and differentiation in Drosophila.

PLoS genetics - 1 Apr 2011

Grice Stuart J, Liu Ji-Long

Abstract excerpt

Spinal muscular atrophy is a severe neurogenic disease that is caused by mutations in the human survival motor neuron 1 (SMN1) gene. SMN protein is required for the assembly of small nuclear ribonucleoproteins and a dramatic reduction of the protein leads to cell death. It is currently unknown ho...

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Identifiers

PMID: 21490958
DOI: 10.1371/journal.pgen.1002030
PMCID: PMC3072375

Genes

SMN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21490958-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Survival motor neuron protein regulates stem cell division, proliferation, and differentiation in Drosophila.PMID 21490958Read ↗

Genome-wide identification of mRNAs associated with the protein SMN whose depletion decreases their axonal localizationSemantic proximity Read ↗

Composition of the Survival Motor Neuron (SMN) complex in <i>Drosophila melanogaster</i>Semantic proximity Read ↗

The SMN Complex at the Crossroad between RNA Metabolism and NeurodegenerationSemantic proximity Read ↗

A novel human-specific splice isoform alters the critical C-terminus of Survival Motor Neuron proteinSemantic proximity Read ↗

SMN Is Essential for the Biogenesis of U7 Small Nuclear Ribonucleoprotein and 3′-End Formation of Histone mRNAsSemantic proximity Read ↗

Spliceosomal small nuclear ribonucleoprotein biogenesis defects and motor neuron selectivity in spinal muscular atrophy.Semantic proximity Read ↗

Developmental arrest of Drosophila survival motor neuron (Smn) mutants accounts for differences in expression of minor intron-containing genesSemantic proximity Read ↗

The activity of the spinal muscular atrophy protein is regulated during development and cellular differentiationSemantic proximity Read ↗

Gemins modulate the expression and activity of the SMN complexSemantic proximity Read ↗

The Survival of Motor Neurons Protein Determines the Capacity for snRNP Assembly: Biochemical Deficiency in Spinal Muscular AtrophySemantic proximity Read ↗

Gemin5 Binds to the Survival Motor Neuron mRNA to Regulate SMN ExpressionSemantic proximity Read ↗

A Drosophila melanogaster model of spinal muscular atrophy reveals a function for SMN in striated muscle.Semantic proximity Read ↗

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