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Article

The doublesex-related Dmrta2 safeguards neural progenitor maintenance involving transcriptional regulation of Hes1.

Proceedings of the National Academy of Sciences of the United States of America - 11 Jul 2017

Young Fraser I, Keruzore Marc, Nan Xinsheng, Gennet Nicole, Bellefroid Eric J, Li Meng

Abstract excerpt

The mechanisms that determine whether a neural progenitor cell (NPC) reenters the cell cycle or exits and differentiates are pivotal for generating cells in the correct numbers and diverse types, and thus dictate proper brain development. Combining gain-of-function and loss-of-function approaches in an embryonic stem cell-derived cortical differentiation model, we report that doublesex- and mab-3-related...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28655839
DOI: 10.1073/pnas.1705186114
PMCID: PMC5514752

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