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The Colibactin-Producing <i>Escherichia coli</i> alters the tumor microenvironment to immunosuppressive lipid overload facilitating colorectal cancer progression and chemoresistance

2023-03-14

Abstract excerpt

<h4>ABSTRACT</h4> Intratumoral bacteria locally contribute to cellular and molecular tumor heterogeneity that support cancer stemness through poorly understood mechanisms. This study aims to explore how Colibactin-producing Escherichia coli (CoPEC) flexibly alters the tumor microenvironment in right-sided colorectal cancer (CRC). Metabolomic and transcriptomic spatial profiling uncovered that CoPEC colonization...

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Literature Corpus work
6ae5be89-7166-57ad-8a12-78455ba52706
DOI
10.1101/2023.03.13.523827
Open publication

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