Article
Mutation enrichment in human DNA samples via UV-mediated cross-linking.
Nucleic acids research - 8 Apr 2022
Leong Ka Wai, Yu Fangyan, Makrigiorgos G Mike
Abstract excerpt
Detection of low-level DNA mutations can reveal recurrent, hotspot genetic changes of clinical relevance to cancer, prenatal diagnostics, organ transplantation or infectious diseases. However, the high excess of wild-type (WT) alleles, which are concurrently present, often hinders identification of salient genetic changes. Here, we introduce UV-mediated cross-linking minor allele enrichment (UVME), a novel...
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