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Article

Winnowing DNA for rare sequences: highly specific sequence and methylation based enrichment.

PloS one - 1 Jan 2012

Thompson Jason D, Shibahara Gosuke, Rajan Sweta, Pel Joel, Marziali Andre

Abstract excerpt

Rare mutations in cell populations are known to be hallmarks of many diseases and cancers. Similarly, differential DNA methylation patterns arise in rare cell populations with diagnostic potential such as fetal cells circulating in maternal blood. Unfortunately, the frequency of alleles with diagnostic potential, relative to wild-type background sequence, is often well below the frequency of errors in currently...

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Identifiers

PMID: 22355378
DOI: 10.1371/journal.pone.0031597
PMCID: PMC3280224

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