Article

FFPE DNA shows two major error profiles derived from deamination of cytosine and methylcytosine that can be mitigated using distinct repair strategies

2023-03-02

Abstract excerpt

Avoiding damage-induced sequencing errors is a critical step for the accurate identification of medium to rare frequency mutations in DNA samples. In the case of FFPE samples, deamination of cytosine moieties represents a major damage resulting in the loss of DNA material and sequencing errors. In this study, we demonstrated that, while damage from deamination of both cytosine and methylated cytosine moieties resu...

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Literature Corpus work: 825fa745-021c-5a77-b26c-281c7669ded9
DOI: 10.1101/2023.03.02.530819

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FFPE DNA shows two major error profiles derived from deamination of cytosine and methylcytosine that can be mitigated using distinct repair strategiesDOI 10.1101/2023.03.02.530819Read

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