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Article

Differential strand separation at critical temperature: a minimally disruptive enrichment method for low-abundance unknown DNA mutations.

Nucleic acids research - 1 Feb 2013

Guha Minakshi, Castellanos-Rizaldos Elena, Liu Pingfang, Mamon Harvey, Makrigiorgos G Mike

Abstract excerpt

Detection of low-level DNA variations in the presence of wild-type DNA is important in several fields of medicine, including cancer, prenatal diagnosis and infectious diseases. PCR-based methods to enrich mutations during amplification have limited multiplexing capability, are mostly restricted t...

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PMID: 23258702
DOI: 10.1093/nar/gks1250
PMCID: PMC3561944

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KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23258702-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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